That depends on whether it is enabling legislation or a siimple straightforward resolution

[eridani]

The latter would be a piece of cake, the former not so much. The more complex a referendum, the more options for people to object to just one part of it. That would be a no vote, plus people who don't understand the details will vote no on general principles.

CA had a referendum on single payer which got fewer votes in favot than there were valid petition signatures. The single payer folks then wisely switched their efforts to working with the state legislature.