The breakthrough medicines that could change the course of Covid
https://www.theguardian.com/world/2020/dec/27/the-breakthough-medicines-that-could-change-the-course-of-covid
The breakthrough medicines that could change the course of Covid
Robin McKie Observer Science Editor
Sun 27 Dec 2020 08.59 GMT
It remains one of the most dramatically successful outcomes in the battle against Covid-19. A cheap treatment for inflammation was found to save lives of seriously ill patients while a trio of much-touted therapies were shown to have no effect.
It is now estimated that the discovery of the effectiveness of the drug dexamethasone has saved around 650,000 lives across the world, according to Professor Martin Landray, a founder of the Recovery programme the worlds largest randomised Covid-19 drugs trial which revealed the medicines anti-Covid properties last summer. In the UK alone, dexamethasone has already prevented more than 12,000 deaths, he told the Observer.
The breakthrough demonstrates the power of large-scale randomised trials in pinpointing effective medicines and will be followed, in the next few weeks, with results from another handful of promising treatments being studied as part of the Recovery programme.
These medicines, which could be crucial in the fight to contain Covid-19 next year, are: convalescent plasma, taken from recovering Covid patients; monoclonal antibodies, made by Regeneron, that were used to treat Donald Trump; two anti-inflammatory drugs, tocilizumab and colchicine; and aspirin. All are undergoing trials carried out by thousands of doctors and nurses on tens of thousands of patients in hospitals across Britain. First results are expected in January or early February.
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