A Potential Game Changer for Type 2 Diabetics - New Therapeutic Target Identified

[SheltieLover]

https://scitechdaily.com/a-potential-game-changer-for-type-2-diabetics-new-therapeutic-target-identified/

By THE MOUNT SINAI HOSPITAL / MOUNT SINAI SCHOOL OF MEDICINE OCTOBER 14, 2022

Insufficient ß – cell mass is the root cause of all major types of diabetes. When blood glucose levels in the body rise, such as in response to a high-fat diet, ? cells respond by creating and releasing more insulin to manage blood glucose levels. Hyperglycemia, or persistently high blood glucose, may, however, hinder the ability of ? cells to produce and secrete insulin. This leads to a vicious cycle of rising glucose levels and declining ?–cell activity, which eventually ends in the death of ? cells, a phenomenon known as glucose toxicity. Thus, ? cell preservation and regeneration are therapeutic goals for diabetes.

The reseadch team found that ChREBP? plays a key role in the gradual destruction of ? cells. Thus, we believe it is a marker of hyperglycemia and glucose toxicity.”

“Traditionally, ChREBP was thought to be a mediator of glucose toxicity, but we noticed one form, ChREBPa, appeared to protect beta cells,” said Donald Scott, Ph.D., a Professor of Medicine (Endocrinology, Diabetes, and Bone Disease) at Icahn Mount Sinai, and a member of DOMI and of The Mindich Child Health and Development Institute. “By using tools we developed that enabled us to interrogate these isoforms independently, we found that ChREBP? plays a key role in the gradual destruction of ? cells. Thus, we believe it is a marker of hyperglycemia and glucose toxicity."

"Moreover, we found that if you remove ChREBP? or counteract it pharmacologically, you can mitigate the effects of glucose toxicity and protect those cells. This exciting discovery creates an opportunity to develop therapeutic agents that target this molecular mechanism, effectively block ChREBP? production, and thus preserve ?-cell mass. This would not only address the challenge that has driven diabetes research for years but also prevents patients with type 2 diabetes from becoming insulin dependent due to loss of ?-cell mass, which would have a significant impact on outcomes and quality of life."

More at link. Hopeful finding, for sure!

[I_UndergroundPanther]

1. Wow

It could really help out us diabetics.
Hope its avaliable soon and at a reasonable price too. Available to medical assistance folks too

[SheltieLover]

2. I hope so, too!

Fingers crossed! 🤞🤞🤞🤞🤞

[Botany]

3. Go β cells!

"Moreover, we found that if you remove ChREBP? or counteract it pharmacologically, you can mitigate
the effects of glucose toxicity and protect those cells.

[SheltieLover]

4. Really exciting news!

Especially with Type 2 & prediabetes being an effect of covid!

Many seniors are insulin dependent, too!

🤞🤞🤞🤞🤞🤞🤞🤞

[lostnfound]

5. Hospital visit for a heart problem followed by insulin dependence

Every time he had a hospital visit they took him off his routine oral meds and let his blood sugar skyrocket, then gave him insulin and told him he needed to stay on it with three shots a day which he HATED. One of those heart meds also kills them off.

Insulin-producing cells killed off by very high blood sugar are hard to regrow. There is a Japanese journal article that found that Japanese fermented bens called natto can help hem regrow. He started having more regulated blood sugar levels after eating that daily for a month or so.

Eventually on one of those visits they took him off his routine blood pressure regulator medicine that kept it slightly elevated, letting it plummet until they stuck him on a ventilator in a panic…then he died.

Hospital;s taking patients off the medicines they routinely take is a plague.