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Tasmanian devils' contagious cancers sequenced for first time.
As some people may know, the survival of Tasmanian Devils has been threatened by the outbreak of contagious facial cancers. (Contagious cancers are rare, thankfully, in most species.)
I will not have time to discuss the full article in Science, but here is a news item from Nature referencing the paper:
Tasmanian devils’ contagious cancers sequenced for first time
Gemma Conroy, Nature News 20 April 2023
Subtitle:
Detailed genetic map pinpoints the tumours’ origins, and hints at their future evolution
Some excerpts if the news item is not open sourced:
For three decades, Tasmanian devils have battled contagious facial cancers that result in debilitating tumours. Now, a comprehensive genetic analysis of these cancers has tracked their evolution, offering clues about how they could spread in future.
The study, published on 20 April in Science1, offers some of the first detailed insights into how the diseases emerged, evolved and spread. This lays the groundwork for modelling how they could affect Tasmanian devil populations in future, says Janine Deakin, a genomicist at the University of Canberra. “Looking at the genomics does give us that insight into the past as well as potentially into the future,” says Deakin. “We need to understand the enemy that we’re working with.”
Devilish diseases
Tasmanian devils (Sarcophilus harrisii) are carnivorous marsupials native to the island of Tasmania in southeast Australia. They are susceptible to two cancers that emerged separately: devil facial tumour 1 (DFT1) and devil facial tumour 2 (DFT2), which are both spread by biting. Cancers that pass from one host to another are rare in nature, but can have devastating effects, says study co-author Rodrigo Hamede, a disease ecologist at the University of Tasmania in Hobart. “In a matter of 10 years, we lost between 60–70% of the overall [devil] population,” he says.
Although scientists have been aware of the two cancers for some time, little has been known about their evolution. To investigate, Hamede and his colleagues assembled a Tasmanian devil reference genome and compared it with DNA sequenced from 78 DFT1 and 41 DFT2 tumours...
...Vulnerable populations
Previous research2 has shown that Tasmanian devil populations are becoming more resilient, but the relatively recent emergence of DFT2 is concerning, says Hannah Siddle, a geneticist at the University of Queensland in Brisbane, Australia. “It leaves the devil vulnerable in the wild, particularly in those regions where both tumours circulate,” she says. “This could induce local population crashes or as-yet unknown selection on the host population.”
Hamede says that more work needs to be done before researchers can predict how the cancers will evolve and spread through remaining Tasmanian devil populations. “This is an ongoing evolutionary process that we have been witnessing in action,” says Hamede. “This second transmissible cancer will make things more complex.”
The study, published on 20 April in Science1, offers some of the first detailed insights into how the diseases emerged, evolved and spread. This lays the groundwork for modelling how they could affect Tasmanian devil populations in future, says Janine Deakin, a genomicist at the University of Canberra. “Looking at the genomics does give us that insight into the past as well as potentially into the future,” says Deakin. “We need to understand the enemy that we’re working with.”
Devilish diseases
Tasmanian devils (Sarcophilus harrisii) are carnivorous marsupials native to the island of Tasmania in southeast Australia. They are susceptible to two cancers that emerged separately: devil facial tumour 1 (DFT1) and devil facial tumour 2 (DFT2), which are both spread by biting. Cancers that pass from one host to another are rare in nature, but can have devastating effects, says study co-author Rodrigo Hamede, a disease ecologist at the University of Tasmania in Hobart. “In a matter of 10 years, we lost between 60–70% of the overall [devil] population,” he says.
Although scientists have been aware of the two cancers for some time, little has been known about their evolution. To investigate, Hamede and his colleagues assembled a Tasmanian devil reference genome and compared it with DNA sequenced from 78 DFT1 and 41 DFT2 tumours...
...Vulnerable populations
Previous research2 has shown that Tasmanian devil populations are becoming more resilient, but the relatively recent emergence of DFT2 is concerning, says Hannah Siddle, a geneticist at the University of Queensland in Brisbane, Australia. “It leaves the devil vulnerable in the wild, particularly in those regions where both tumours circulate,” she says. “This could induce local population crashes or as-yet unknown selection on the host population.”
Hamede says that more work needs to be done before researchers can predict how the cancers will evolve and spread through remaining Tasmanian devil populations. “This is an ongoing evolutionary process that we have been witnessing in action,” says Hamede. “This second transmissible cancer will make things more complex.”
The references are these:
1) Stammnitz, M. R. et al. Science 380, 283–293 (2023).
2) Stahlke, A. R. et al. Proc. R. Soc. B 288, 20210577 (2021)
I may pick up the references if I have time over the weekend.
Have a pleasant Friday and weekend.