Welcome to DU!
The truly grassroots left-of-center political community where regular people, not algorithms, drive the discussions and set the standards.
Join the community:
Create a free account
Support DU (and get rid of ads!):
Become a Star Member
Latest Breaking News
Editorials & Other Articles
General Discussion
The DU Lounge
All Forums
Issue Forums
Culture Forums
Alliance Forums
Region Forums
Support Forums
Help & Search
Psilocybin desynchronizes the human brain
https://www.nature.com/articles/s41586-024-07624-5(full text, pdf, more, at link)
Article
Open access
Published: 17 July 2024
Psilocybin desynchronizes the human brain
Joshua S. Siegel, Subha Subramanian, Demetrius Perry, Benjamin P. Kay, Evan M. Gordon, Timothy O. Laumann, T. Rick Reneau, Nicholas V. Metcalf, Ravi V. Chacko, Caterina Gratton, Christine Horan, Samuel R. Krimmel, Joshua S. Shimony, Julie A. Schweiger, Dean F. Wong, David A. Bender, Kristen M. Scheidter, Forrest I. Whiting, Jonah A. Padawer-Curry, Russell T. Shinohara, Yong Chen, Julia Moser, Essa Yacoub, Steven M. Nelson, …Nico U. F. Dosenbach
Nature (2024)
Abstract
A single dose of psilocybin, a psychedelic that acutely causes distortions of space–time perception and ego dissolution, produces rapid and persistent therapeutic effects in human clinical trials1,2,3,4. In animal models, psilocybin induces neuroplasticity in cortex and hippocampus5,6,7,8. It remains unclear how human brain network changes relate to subjective and lasting effects of psychedelics. Here we tracked individual-specific brain changes with longitudinal precision functional mapping (roughly 18 magnetic resonance imaging visits per participant). Healthy adults were tracked before, during and for 3?weeks after high-dose psilocybin (25?mg) and methylphenidate (40?mg), and brought back for an additional psilocybin dose 6–12?months later. Psilocybin massively disrupted functional connectivity (FC) in cortex and subcortex, acutely causing more than threefold greater change than methylphenidate. These FC changes were driven by brain desynchronization across spatial scales (areal, global), which dissolved network distinctions by reducing correlations within and anticorrelations between networks. Psilocybin-driven FC changes were strongest in the default mode network, which is connected to the anterior hippocampus and is thought to create our sense of space, time and self. Individual differences in FC changes were strongly linked to the subjective psychedelic experience. Performing a perceptual task reduced psilocybin-driven FC changes. Psilocybin caused persistent decrease in FC between the anterior hippocampus and default mode network, lasting for weeks. Persistent reduction of hippocampal-default mode network connectivity may represent a neuroanatomical and mechanistic correlate of the proplasticity and therapeutic effects of psychedelics.
Main
Psychedelic drugs can reliably induce powerful acute changes in the perception of self, time and space by agonism of the serotonin 2A (5-HT2A) receptor9,10. In clinical trials, a single high dose of psilocybin (25?mg) has demonstrated rapid and sustained symptom relief in depression1,2,3,11,12,13,14, addiction4,15 and end-of-life anxiety13,14. Together, these observations indicate that psychedelics should induce potent acute (lasting roughly 6?hours) and persistent (24?hours to 21?days) neurobiological changes.
Open access
Published: 17 July 2024
Psilocybin desynchronizes the human brain
Joshua S. Siegel, Subha Subramanian, Demetrius Perry, Benjamin P. Kay, Evan M. Gordon, Timothy O. Laumann, T. Rick Reneau, Nicholas V. Metcalf, Ravi V. Chacko, Caterina Gratton, Christine Horan, Samuel R. Krimmel, Joshua S. Shimony, Julie A. Schweiger, Dean F. Wong, David A. Bender, Kristen M. Scheidter, Forrest I. Whiting, Jonah A. Padawer-Curry, Russell T. Shinohara, Yong Chen, Julia Moser, Essa Yacoub, Steven M. Nelson, …Nico U. F. Dosenbach
Nature (2024)
Abstract
A single dose of psilocybin, a psychedelic that acutely causes distortions of space–time perception and ego dissolution, produces rapid and persistent therapeutic effects in human clinical trials1,2,3,4. In animal models, psilocybin induces neuroplasticity in cortex and hippocampus5,6,7,8. It remains unclear how human brain network changes relate to subjective and lasting effects of psychedelics. Here we tracked individual-specific brain changes with longitudinal precision functional mapping (roughly 18 magnetic resonance imaging visits per participant). Healthy adults were tracked before, during and for 3?weeks after high-dose psilocybin (25?mg) and methylphenidate (40?mg), and brought back for an additional psilocybin dose 6–12?months later. Psilocybin massively disrupted functional connectivity (FC) in cortex and subcortex, acutely causing more than threefold greater change than methylphenidate. These FC changes were driven by brain desynchronization across spatial scales (areal, global), which dissolved network distinctions by reducing correlations within and anticorrelations between networks. Psilocybin-driven FC changes were strongest in the default mode network, which is connected to the anterior hippocampus and is thought to create our sense of space, time and self. Individual differences in FC changes were strongly linked to the subjective psychedelic experience. Performing a perceptual task reduced psilocybin-driven FC changes. Psilocybin caused persistent decrease in FC between the anterior hippocampus and default mode network, lasting for weeks. Persistent reduction of hippocampal-default mode network connectivity may represent a neuroanatomical and mechanistic correlate of the proplasticity and therapeutic effects of psychedelics.
Main
Psychedelic drugs can reliably induce powerful acute changes in the perception of self, time and space by agonism of the serotonin 2A (5-HT2A) receptor9,10. In clinical trials, a single high dose of psilocybin (25?mg) has demonstrated rapid and sustained symptom relief in depression1,2,3,11,12,13,14, addiction4,15 and end-of-life anxiety13,14. Together, these observations indicate that psychedelics should induce potent acute (lasting roughly 6?hours) and persistent (24?hours to 21?days) neurobiological changes.
2 replies
= new reply since forum marked as read
= new reply since forum marked as read
