Science

NNadir

(34,682 posts)

38. How long were you sick? I didn't realize that Paxlovid was a combination drug, with the old...

Thu Jan 12, 2023, 12:31 PM

Jan 2023

...protease inhibitor ritonavir working to block CYP metabolism of nirmatrelvir. (I just looked it up.)

(I was briefly involved with the scale up of ritonavir, but worked mostly on saquinavir, and nelfinavir. Someone actually posted the full synthetic pathway for ritonavir in a poster session at an ACS meeting, even though it was proprietary. Coming across that that got me some "brownie points" in my company.)

I'm an old guy; I still love peptidomimetics.

I assume you took it; my wife is declining to do so, probably for good reason.

How long were you guys sick? Do you feel the Paxlovid helped?

Edit history

Please sign in to view edit histories.

50 replies

= new reply since forum marked as read

Highlight:

Some pretty bad news on the XBB.1 Covid Variant. [View all] NNadir Jan 2023 OP

my understanding is that they are working on vaccines and treatments lapfog_1 Jan 2023 #1

Yes, I have heard that peripherally, but have not looked into it any detail. I will though. n/t. NNadir Jan 2023 #2

Yes universal are in pipeline IbogaProject Jan 2023 #26

Yes, have read a bit about it. It would work on the spine that holds the spikes. PortTack Jan 2023 #23

Grrrrr. lark Jan 2023 #3

My wife and I are nearly over this NewHendoLib Jan 2023 #4

How long were you sick? I didn't realize that Paxlovid was a combination drug, with the old... NNadir Jan 2023 #38

Hi there! read on below NewHendoLib Jan 2023 #40

Sorry to hear you and your wife have been mnhtnbb Jan 2023 #47

We've been masking constantly when we're out/about. woodsprite Jan 2023 #5

Florida should never be a destination SuperCoder Jan 2023 #14

That's why I'm just assuming he's coming back with it. woodsprite Jan 2023 #16

Yes, with all of Ron DeFuckwit's lying KS Toronado Jan 2023 #20

I recently cancelled a trip to FL planned mnhtnbb Jan 2023 #48

Day 14?! That's discouraging! deurbano Jan 2023 #18

get a bunch of hepa filters for the house to help nt orleans Jan 2023 #39

I hope that your family members begin to feel better soon. TexasTowelie Jan 2023 #6

That could be where I heard it, from your post. I didn't look in the primary literature though. NNadir Jan 2023 #7

That's odd, I was able to open it without any difficulty. TexasTowelie Jan 2023 #10

It's OK. They mentioned the name of Kayvon Modjarrad in the abstract of the article. NNadir Jan 2023 #13

Thx for the info SheltieLover Jan 2023 #8

Sorry your son is sick, but thank him for at least starting to answer the question re: efficacy of hlthe2b Jan 2023 #9

Thank you for this Abigail_Adams Jan 2023 #11

Thank you for posting this. hay rick Jan 2023 #12

My wife just tested positive yesterday. ificandream Jan 2023 #15

Wishing the best for you and your family, and thanks for the update. nt eppur_se_muova Jan 2023 #17

My wife went from 0 to I'll on 11/27 after we visited.... jaxexpat Jan 2023 #19

Thank you for researching and sharing with us. MLAA Jan 2023 #21

I'm so sorry this is happening to you. Silver Gaia Jan 2023 #22

Answers to your questions: NNadir Jan 2023 #25

I'm so glad your wife is doing better! Silver Gaia Jan 2023 #36

I've been masking. ananda Jan 2023 #24

I hope you are all able to come through this without long-term Covid issues. Bluethroughu Jan 2023 #27

Dogs can get it Farmer-Rick Jan 2023 #34

Thank you. Stay well. I hope everyone recovers quickly. Wicked Blue Jan 2023 #28

Thank you for the very informative post & best wishes HuskyOffset Jan 2023 #29

American made N95 masks are cheap and widely available now IronLionZion Jan 2023 #30

NYC isn't very masked anymore IbogaProject Jan 2023 #32

Same with DC, but I still wear a mask on transit, airports, and crowded indoor spaces IronLionZion Jan 2023 #33

it's not just MAGAts refusing to mask Skittles Jan 2023 #45

I hope your family feels better soon. herding cats Jan 2023 #31

Great post with good information LetMyPeopleVote Jan 2023 #35

best wishes for you and your family getting through this quickly nt orleans Jan 2023 #37

Markedly more contagious but less virulent is what I've been reading Warpy Jan 2023 #41

Thank you for the detailed info! It makes me feel justified in continuing to mask up in public and LaMouffette Jan 2023 #42

We must keep the economy open at all costs and pretend that vaccination alone is sufficient Orrex Jan 2023 #43

All the best to you. Are we supposed to get the booster again? We had ours at the end of September... Hekate Jan 2023 #44

I'm not a physician, however, as I read this, the booster would be ineffective. A new vaccine... NNadir Jan 2023 #50

Thank You for posting This❗My son also contracted a case of Covid Duppers Jan 2023 #46

Thanks for posting this. mnhtnbb Jan 2023 #49