The Effect of PFAS on Colorectal Cancer: Some bad news.

[NNadir]

4. Almost all modern toxicological work begins with cell based assays, as do many screens for therapeutic value.

I agree that one can always expand upon cell work, and one should do so, although there is a very active movement to minimize animal studies by substituting, beyond cells, tissues.

This said there is some epidemiological reference in the full paper describing - as alluded in my excerpt - to higher rates of CRC among people how have high levels of exposure to PFAS, notably firefighters with exposure to PFAS based AFFF.

If funded, it may be possible to compare CRC patients, particularly those with KRAS oncogenes for serum or plasma levels of PFAS with a control group.

There are many thousands of studies in the literature on PFAS levels in human and animal tissue.